Turning Human Pluripotent Stem Cells Into Mesoderm That Forms Kidney Tubules

Hemodialysis.com Interview with: Albert Q. Lam, MD Harvard Medical School, Boston, MA More »

ACEIs/ARBs Lowered Dialysis Risk in CKD Hypertensive Patients

Hemodialysis.com Interview with: Dr. Der-Cherng Tarng and Dr. Chih-Cheng Hsu. More »

Kidney Stones: Value of Weekly Exercise

Hemodialysis.com Interview with: Mathew Sorensen, MD, MS More »

Albuminuria and Exposure to Phthaltes

Hemodialysis.com Interview with: Dr. Howard Trachtman MD More »

Urinary Biomarkers Predict AKI, With or Without Other Organ Failures

Hemodialysis.com Interview with:

Dr. John Kellum

Dr. John Kellum

John A. Kellum, MD, MCCM
Tenured Professor, Critical Care Medicine
Professor of Medicine, Bioengineering and Clinical & Translational Science
Vice Chair for Research
Director, Center for Critical Care Nephrology
Director, Center for Assistance in Research using eRecord (CARe) and

 

Dr. Patrick Honore

Dr. Patrick Honore

Dr. Patrick M. Honore, MD PhD
Department of Intensive Care Medicine
Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel
VUB School of Medicine
Brussels, Belgium

Hemodialysis.com: What is the background for this study?

Response:

  • 1)We conducted a preplanned subgroup analysis of critically ill patients enrolled in either of our two previously reported studies on the discovery/validation (Sapphire) [1] and subsequent secondary validation (Topaz) [1] of tissue inhibitor of
    metalloproteinase-2 [TIMP-2] and insulin-like growth factor-binding protein 7
    [IGFBP7]. We defined sepsis based on international consensus criteria and the clinical diagnosis assigned by the treating physicians at enrolling sites. All patients were considered to be at high risk for acute kidney injury (AKI), characterized by respiratory or cardiovascular dysfunction as previously reported in our two initial studies [1,2]. We assessed severity of illness and organ dysfunction/failure with the Acute Physiology and Chronic Health Evaluation (APACHE) III and Sequential Organ Failure Assessment (SOFA) scores. Non renal APACHE III and SOFA scores were calculated by subtracting the renal components from these scores.
  • 2)We were particularly interested to see if septic AKI was well predicted by urinary [TIMP-2] & [IGFBP7].
  • 3)The second point of interest was to see if the validity of the urinary biomarkers were affected or not by the number of other failures (calculated as non renal SOFA score).

1/3 Hemodialysis Patients Receive Antibiotics in Course of Year

Hemodialysis.com Interview with:

Graham M. Snyder, MD, SM Division of Infectious Diseases Beth Israel Deaconess Medical Center MA 02215

Dr. Graham Snyder

Graham M. Snyder, MD, SM
Division of Infectious Diseases
Beth Israel Deaconess Medical Center
MA 02215

Hemodialysis.com: What is the background for this study? What are the main findings?

Response: Evidence is accumulating that in both inpatient and outpatient settings, there are substantial improvements to be made in the appropriateness of antimicrobial prescribing. The chronic hemodialysis population is particularly vulnerable to developing infections with multidrug-resistant organisms (MDRO) due to their contact with the healthcare setting, risk of infection, and high frequency of antimicrobial use.

In our detailed investigation of antimicrobial use over 12 months in two outpatient hemodialysis units, one third of patients received at least 1 dose of antimicrobials and more than half of these patients received at least 1 inappropriately indicated antimicrobial. Having a tunneled catheter for hemodialysis access and a history of multidrug-resistant organisms colonization or infection were among the factors associated with antimicrobial use. Tunneled catheter access was also associated with inappropriate antimicrobial use.

Canagliflozin (Invokana, Invokamet) and Dapagliflozin (Farxiga, Xigduo XR): Drug Safety Communication – Strengthened Kidney Warnings

ISSUE: FDA has strengthened the existing warning about the risk of acute kidney injury for the type 2 diabetes medicines canagliflozin (Invokana, Invokamet) and dapagliflozin (Farxiga, Xigduo XR).  Based on recent reports, we have revised the warnings in the drug labels to include information about acute kidney injury and added recommendations to minimize this risk.

BACKGROUND: Canagliflozin and dapagliflozin are prescription medicines used with diet and exercise to help lower blood sugar in adults with type 2 diabetes.  They belong to a class of drugs called sodium-glucose cotransporter-2 (SGLT2) inhibitors.  Canagliflozin and dapagliflozin lower blood sugar by causing the kidneys to remove sugar from the body through the urine.

From March 2013, when canagliflozin was approved, to October 2015, FDA received reports of 101 confirmable cases* of acute kidney injury, some requiring hospitalization and dialysis, with canagliflozin or dapagliflozin use (see Drug Safety Communication for the Data Summary).  This number includes only reports submitted to FDA, so there are likely additional cases about which we are unaware. 

UnitedHealthcare Will Reimburse Kidney Donors’ Travel Expenses, Expanding Life-Saving Access to Kidney Transplants

BOSTON (June 13, 2016) – UnitedHealthcare will pay travel expenses for kidney transplant donors, addressing one of the major barriers to living organ donation.

The announcement was made yesterday at the 2016 American Transplant Congress in Boston by Jon Friedman, M.D., chief medical officer for Optum’s Complex Medical Conditions programs. Optum is the health services company that manages transplant services for UnitedHealthcare. Both companies are collaborating with the American Society of Transplantation (AST) and American Society of Transplant Surgeons (ASTS), which hosted the congress, to improve outcomes, reduce costs and enhance the experience of donors and recipients.

UnitedHealthcare will be the largest payer to directly reimburse living donors, from the start of their evaluation process, through follow-up visits two years post-donation. The donor does not need to be enrolled in a UnitedHealthcare plan to qualify for reimbursement.

“Many healthy people are eligible to donate a kidney, yet only one-third of kidney transplants come from living donors,” said Friedman, who has clinical oversight and responsibility for transplantation and chronic and end-stage kidney disease for Optum. “This initiative will make it easier for living kidney donors to provide a life-saving gift to patients and their families.”

According to the AST, 96 percent of kidney donors experience donation-related financial consequences.

Starting in 2017, UnitedHealthcare will reimburse up to $5,000 toward lodging and travel expenses for living kidney donors. The travel reimbursement will be offered on top of existing coverage of medical expenses associated with a kidney transplant for both the recipient and the living donor.

While the need for kidney transplants continues to increase, the number of donor kidneys falls far short of demand. In 2015, only about one in five people on the kidney transplant waiting list received a transplant, according to the Organ Procurement and Transplantation Network (OPTN). Living donors are the best source to increase the pool of kidneys available for transplantation.

“The American Society of Transplant Surgeons applauds UnitedHealthcare and Optum for taking this significant step toward reducing the financial barriers to living organ donation, and we look forward to working with them and other partners to make it possible for everyone who wants to donate an organ to do so,” said Charlie Miller, M.D., president of ASTS.

James Allan, M.D., president of the American Society of Transplantation, added: “UnitedHealthcare and Optum’s efforts to address the issue of late-stage kidney disease are significant. We hope this is only the first step as our health care system works to remove financial and other barriers to organ donation.”

UnitedHealthcare plans will reimburse lodging and travel expenses for the kidney donor and a companion, starting with the donor’s initial evaluation to determine suitability, through follow-up evaluations up to two years after donor surgery. The travel reimbursement, up to $5,000, will be available for all donors whose intended transplant recipients are enrolled in UnitedHealthcare fully insured plans as of the new policy year, Jan. 1, 2017.

NKF Honors NKF Rapper and Dialysis Patient Freeway

Rapper Freeway and Dr. Robert Benz NKF Award Recipients

Rapper Freeway and Dr. Robert Benz NKF 2016 Award Recipients

Philadelphia, PA — February 17, 2016 – Philadelphia-based MC has been selected as the recipient of the National Kidney Foundation (NKF)’s Patient Advocacy Award. Freeway will be honored on World Kidney Day, Thursday, March 10, 2016 at the NKF Honors Awards Reception in Philadelphia. During September 2015, without warning, the 37-year-old State Property MC and North Philadelphia native was diagnosed with kidney failure.

Currently undergoing dialysis three times a week, Freeway is committed to raising awareness of kidney disease and ensuring Philadelphians stay on top of their kidney health. In October, Freeway hosted and helped kick off the Kidney Walk in Philadelphia at the Philadelphia Museum of Art. The event drew over 4,000 walkers who helped raise awareness and funds to support the fight against kidney disease. “It is a pleasure to be presenting Freeway with the Patient Advocacy Award at March’s NKF Honors Award Ceremony,” said Christin Naab, Executive Director of the National Kidney Foundation in Philadelphia. “Freeway remains committed to sharing his story on local and national platforms, encouraging the public to learn kidney disease risk factors and to get their kidneys checked.”

Alongside Freeway, NKF will honor Joseph Cosgrove, President and CEO of Pentec Health with the Leadership in Business Award, nephrologist Dr. Robert Benz, of Lankenau Medical Center with the Excellence in Care Award and Mrs. Tina Wilson, of Team Wilson/Wilmington University with the Community Leadership Award.

National Kidney Foundation Honors Lankenau Medical Center Nephrologist at Annual Awards Ceremony

NKF Press Release:

Wynnewood, PA– February 17, 2016 –Dr. Robert Benz, nephrologist of Lankenau Medical Center, has been selected as the recipient of the National Kidney Foundation (NKF)’s Excellence in Care Award.
Dr. Benz will be honored on World Kidney Day, Thursday, March 10, 2016 at the NKF Honors Awards Reception in Philadelphia. Dr. Robert Benz is the Chief of the Division of Nephrology at Main Line Health and Lankenau and has been caring for Philadelphia area kidney patients for over 30 years. He is also currently Director of the Nephrology Fellowship Program and has trained numerous residents and fellows with teaching being a major part of career and mission, utilizing the knowledge and education that he gained during his years at Penn.

He currently sits on the NKF’s Medical Advisory Board along with many other leadership roles in the field. “It is a pleasure to be presenting Dr. Benz with the Excellence in Care Award at March’s NKF Honors Award Ceremony,” said Christin Naab, Executive Director of the National Kidney Foundation in Philadelphia. “Dr. Benz and Lankenau Medical Center are committed to improving the health and quality of life for kidney patients and help to provide top quality care right here in the Delaware Valley.”

Alongside Dr. Benz, NKF will honor Joseph Cosgrove, President and CEO of Pentec Health with the Leadership in Business Award, Tina Wilson, of Team Wilson/Wilmington University with the Community Leadership Award and Philadelphia native and MC Freeway, with the Patient Advocacy Award. NKF Honors is the NKF’s annual affair that honors those in the communities who have made a difference in the lives of kidney patients and have advanced the mission of the National Kidney Foundation. The Kidney Ball is one of NKF’s largest annual fundraisers and is anticipated to raise over $300,000 for the organization’s awareness, prevention, and treatment programs. Those interested in attending or sponsoring can find more information online at www.nkfdv.org

Peritoneal Dialysis: Skin Autofluorescence Correlates With Increased Heart Disease and Mortality Risk

Hemodialysis.com Interview with:
Emília Mácsai MD. PhD. nephrologist, diabetologist

Emília Mácsai MD. PhD. nephrologist, diabetologist

 

Attila Benke MD. Medical Director 3-rd Dialysiscentre BBRAUN Hungarian Network
Attila Benke MD.
Medical Director 3-rd Dialysiscentre BBRAUN Hungarian Network

 

 

Professor B. BraunProfessor B. Braun
Professor B. Braun

Semmelweis University Budapest 2-nd Department of Internal Medicine Geriatrics Group
Medical Director 1-st Dialyiscentre BBRAUN Hungarian Network

 

Hemodialysis.com: What are the main finding of the study? Were any of the findings unexpected?

Response: Advanced glycation end-products are well-known markers of cardiovascular mortality in hemodialysed patients, they represent subgroup of uremic toxins and molecular mediators of diabetic complications. Their tissue accumulation is measurable with a special AGE Reader device. Skin autofluorescence evaluating with this simple non-invasive method signs in our study the previous cumulative glucose burden (higher rates in case of diabetes), correlates with presence of cardiovascular disease and in 3 years term predicts mortality in patients on peritoneal dialysis. Peritoneal glucose exposure and elapsed time in peritoneal dialysis also connected with skin autofluorescence, which indicate  additional dialysis-associated glycemic effect.

Hemodialysis.com: What should clinicians and patients take away from this study?

Response: This method seems to be suitable to evaluate the extent of long-term damage in connective tissues caused by diabetes and decreased renal elimination of advanced glycation end-products, and signifies patients with high cardiovascular risk in this vulnerable population. Helps us to recognize patients who mostly need for non-glucose based peritoneal solution and multidisciplinary intervention.
Hemodialysis.com: What recommendations do you have for future research as a result of your study?

Response: More biocompatible low glucose peritoneal dialysis solutions should be introduced more extensively, further result could prove their advantageous effect on skin autofluorescence and simultaneous changes in mortality and cardiovascular events.

Citation:

 

Background Skin autofluorescence (SAF) is a proven prognostic factor of mortality in hemodialysis patients. Traditional and non-traditional risk components are similar in peritoneal dialysis (PD), and as well cardiovascular disease (CVD) is the leading cause of death. Moreover peritoneal glucose absorption accelerates degenerative processes of the connective tissues, like in diabetes. In our study we examined the predictive value of SAF for mortality in PD population.

Methods Data were taken from 198 prevalent adult Caucasian PD patients, 126 of them (mean age 66.2 year; male 73; diabetes ratio 75/126) had anamnestic CVD (coronary heart disease, cerebrovascular disease, peripheral arterial disease). Initially we evaluated the factors affecting SAF and CVD by multivariate linear regression. Registering the clinical and demographic data associations with mortality during the next 36 months survival were estimated using Kaplan-Meier method, analysis were stratified on presence of CVD and SAF level above or below the upper tercils 3.61.

Results SAF was influenced by CVD (p<0.01; CI 0.1-0.5) and white blood cell count (p<0.001; CI 0.031-0.117). According Spearman correlation it connected with  peritoneal cumulative glucose exposure (p=0.02) and elapsed time in PD (p=0.008). CVD related with age (p<0.001; CI 1.24-1.65) and diabetes (p<0.001; CI 2.58-10.66). More death were observed in the high SAF group, than in the low SAF group (34/68 v. 44/130; p=0.04). Comparing the CVD(-) low SAF group survival (mean 33.9 month; SE 1.39) to CVD(+) low SAF  (mean 30.5 month; SE 1.37; p=0.03) and to CVD(+) high SAF group (mean 27.1; month; SE 1.83; p=0.001) the difference was significant.

Conclusions Among patients on PD the SAF value over 3.61 seems to be predictor of mortality. Relationship with glucose-exposure, CVD and diabetes suggests its suitability to characterize systemic cumulative glucose load.

 

Not for specific medical advice. Please consult your physician for recommendations and questions. Editor: Marie Benz info@hemodialysis.com