Turning Human Pluripotent Stem Cells Into Mesoderm That Forms Kidney Tubules

Hemodialysis.com Interview with: Albert Q. Lam, MD Harvard Medical School, Boston, MA More »

ACEIs/ARBs Lowered Dialysis Risk in CKD Hypertensive Patients

Hemodialysis.com Interview with: Dr. Der-Cherng Tarng and Dr. Chih-Cheng Hsu. More »

Kidney Stones: Value of Weekly Exercise

Hemodialysis.com Interview with: Mathew Sorensen, MD, MS More »

Albuminuria and Exposure to Phthaltes

Hemodialysis.com Interview with: Dr. Howard Trachtman MD More »

Contast-Induced AKI: Using Renal Function–Adjusted Contrast Volume Before PCI

Hemodialysis.com Interview with:
Giuseppe Andò, MD PhD
University of Messina
Messina, Italy.

Hemodialysis.com: What are the main findings of the study?

Dr. Andò: The volume of contrast media remains a key factor for developing acute
kidney injury after percutaneous coronary intervention for acute myocardial
infarction across the whole spectrum of baseline risk estimation that, in
turn, is based on clinical presentation. Indeed, age, renal function and
left ventricular function are pre-procedural independent predictors of
acute kidney injury and can be combined in a statistical model for risk
estimation which has high discriminative power and calibration. The
addition of the adjusted volume of contrast media (namely, the ratio
contrast volume/estimated glomerular filtration rate) to the model improves
its statistical performance and demonstrates a significant net
reclassification improvement, largely driven by a correct decrease in risk
estimates for patients not experiencing acute kidney injury.

Kidney and Cardiac Function Interplay Begins Prior To Symptomatic Heart or Kidney Disease

 

Elisabet Nerpin PhD. Department of Public Health and Caring Sciences Uppsala University, SwedenHemodialysis.com Interview with:
Elisabet Nerpin PhD.
Department of Public Health and Caring Sciences
Uppsala University, Sweden

Hemodialysis.com: What are the main findings of the study?

Dr. Nerpin: We investigated cross-sectional associations between eGFR (cystatin C-based) and ventricular functional in two community-based samples of elderly, free from a clinical heart failure and with a left ventricular ejection function >40%. Our data suggest that the interplay between kidney and the heart function begins prior to the development of symptomatic heart failure and kidney disease.

Temporal Association Between Warfarin and Aortic Stiffness Progression

Hemodialysis.com Interview with:
Dr. Mohsen Agharazi

CHU de Québec Research Center, L’Hôtel-Dieu de Québec Hospital
Division of Nephrology, Faculty of Medicine, Université Laval
Québec , Canada

Hemodialysis.com: What are the main findings of the study?

Dr. Agharazii: This is the first study to show that there is a temporal association between the use of warfarin and accelerated progression of aortic stiffness. This accelerated progression of aortic stiffness was also associated with increased risk of mortality. Our results also support that subclinical vitamin K deficiency, which is common in dialysis population, may be deleterious to the vascular health in the procalcifying uremic milieu.

Does Remote Ischemic Preconditioning Prevent Acute Kidney Injury?

Hemodialysis.com Interview with:
Jiang-hua Chen MD
Kidney Disease Center
The First Affiliated Hospital
Zhejiang University

Hemodialysis.com: What are the main findings of the study?

Answer: We wanted to confirm the evidence of effects of Remote Ischemic Preconditioning (RIPC) on the prevention of postoperative kidney injury in patients who are undergoing cardiac and vascular interventions. We conducted a systematic review and meta-analysis enrolled 1,334 participants in  13 studies. The results showed Remote Ischemic Preconditioning decreased the risk of AKI for patients undergoing cardiac and vascular interventions compared with the control group. But there were no differences in levels of serum creatinine and glomerular filtration rate, incidence of renal replacement therapy, in-hospital mortality, hospital stay, or intensive care unit stay between the 2 groups.

Chronic Kidney Disease in Children: Medication Adherence and Growth

Hemodialysis.com Interview with:
Oleh Akchurin, M.D.
Assistant Professor of Pediatrics
Division of Nephrology
Weill Cornell Medical College
New York – Presbyterian
Phyllis and David Komansky Center for Children’s Health

Hemodialysis.com: What are the main findings of the study?

Dr. Akchurin: This study demonstrated that self-reported non-adherence to recombinant human growth hormone (rhGH) administration was associated with worsening growth velocity, as compared with those children that reported to be adherent to this therapy in Chronic Kidney Disease in Children (CKiD) cohort study. This finding confirms the importance of adherence to prescribed therapies in controlling CKD co-morbidities in pediatric patients, specifically as it related to growth. It also supports the utility of self reports as a simple and yet effective tool for adherence assessment and monitoring in this category of patients.

Young Black Dialysis Patients Have Increased Mortality Compared To Whites

Tanya Johns, MD, MHS Assistant Professor of Medicine Medical Director, Kidney Care Program and Telehealth Initiative Department of Medicine, Division of Nephrology Albert Einstein College of Medicine, Montefiore Medical Center Bronx, NY 10467Hemodialysis.com Interview with:
Tanya Johns, MD, MHS
Assistant Professor of Medicine
Medical Director, Kidney Care Program and Telehealth Initiative
Department of Medicine, Division of Nephrology
Albert Einstein College of Medicine, Montefiore Medical Center
Bronx, NY 10467

Hemodialysis.com: What are the main findings of the study?

Dr. Johns: We wanted to understand whether the wealth of patients’ neighborhoods contributed to greater rates of death among young black adults compared to young white adults on dialysis. We used income data from the U.S. Census Bureau to classify the wealth of neighborhoods of patients with kidney failure to accomplish this. Young black adults living in poor neighborhoods had higher risk of death compared to all other young black and white adults.  When we looked only among young adults living in poor neighborhoods, young black adults had approximately 1.5 times greater risk of death compared to young white adults. We also found similar survival between young black and white adults on dialysis living in wealthier neighborhoods. These findings were not explained by medical factors including the cause of patients’ kidney failure or other health conditions such as diabetes or high blood pressure.

Kidney Transplantation vs Intensive Home Hemodialysis: Survival and Hospitalization Rates

Hemodialysis.com Interview with:
Dr. Karthik Tennankore
Division of Nephrology
Dalhousie University
Halifax, NS, Canada

MedicalResearch:  What are the main findings of the study?

Dr. Tennankore:  A study comparing Canadian transplant recipients and intensive home hemodialysis patients (IHHD, defined as >=16 hours of home hemodialysis) with respect to risk of death, treatment failure or hospitalization has not been conducted. In this study, we found that patient and treatment survival after kidney transplantation was superior to patient and treatment survival after initiation of intensive home hemodialysis . We defined treatment failure as inability to maintain on IHHD (for any reason other than transplantation) for the dialysis group, and graft failure for transplant recipients. There was a higher risk of hospitalization for transplant recipients in the short term, but after a year, hospitalization risk was lower compared to IHHD patients.

Latest update: 31-7-2014 . Thank you for visitng Hemodialysis.com

Not for specific medical advice. Please consult your physician for recommendations and questions. Editor: Marie Benz info@hemodialysis.com