Category Archives: Diabetes
Influence of Wasting on Hyperparathyroidism in Black Diabetic Hemodialysis Patients
Hemodialysis.com Interview with Rapeepat Lekkham, MD
Nephrology Fellow,
Albert Einstein Medical Center,
Philadelphia, PA
Hemodialysis.com: What are the main findings of the study?
Dr. Lekkham: We conducted the retrospective study on hemodialysis patients who mainly (92.9%) were black and stratified by the absence or presence of wasting syndrome (which defined by serum albumin less than 3.8 g/dl, normalized protein nitrogen appearance (nPNA) less than 0.8 g/kg/day and BMI less than 23 kg/m2) and the association with secondary hyperparathyroidism. Compared to non-diabetic patients, our study found that diabetic patients had a higher mean serum iPTH. Also, serum iPTH was higher in all diabetic non-wasting subgroups patients as well. Other related parameters including mean serum phosphate, serum alkaline phosphatase, the requirement of cinacalcet, vitamin D analogues and phosphate binders were comparable in both groups.
Marie Benz, MD on Google+The GFR and GFR decline cannot be accurately estimated in type 2 diabetics
Hemodialysis.com Authors’ Interview
- Piero Ruggenenti MDPiero Ruggenenti, Mario Negri Institute for Pharmacological Research, Centro Anna Maria Astori, Science and TechnologyPark Kilometro Rosso, Via Stezzano, 87, 24126 Bergamo, Italy
- Flavio Gaspari ChemDClinical ResearchCenter for Rare Diseases ‘Aldo & Cele Daccò’,
Mario Negri Institute for Pharmacological Research, Bergamo, Italy - Esteban PorriniNephrology Section and Research Unit, Hospital Universitario de Canarias,
University of La Laguna, Tenerife, Canary Islands, Spain - Giuseppe Remuzzi MDClinical ResearchCenter for Rare Diseases ‘Aldo & Cele Daccò’,
Mario Negri Institute for Pharmacological Research, Bergamo, Italy
Unit of Nephrology, Azienda Ospedaliera ‘Ospedali Riuniti di Bergamo’, Bergamo, Italy
Hemodialysis.com: What are the main findings of the study?
Response: The main finding of our study was that in hypertensive type 2 diabetes, subjects with normo- or micro-albuminuria, estimation formulas fail to detect glomerular hyperfiltration and to reliably describe GFR changes over time.
Baseline GFR was significantly underestimated by all formulas and a six-month GFR reduction was fully missed, in particular in hyperfiltering patients.
Long-term GFR decline was also underestimated by all formulas in the whole study group, as well as in hyper-, normo- and hypofiltering patients considered separately.
Developing an HbA1c-Based Equation to Estimate Blood Glucose in Maintenance Hemodialysis Patients
Hemodialysis.com Authors’ Interview:
Dr. Junichi Hoshino, MD, MPH
Harold Simmons Center for Chronic Disease Research and Epidemiology
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California
Department of Epidemiology, UCLA School of Public Health Los Angeles, California
Nephrology Center, Toranomon Hospital, Tokyo, Japan
Dr. Kalantar-Zadeh, MD, MPH, PhD
Professor & Chief, Division of Nephrology & Hypertension
University of California Irvine, School of Medicine
Adjunct Professor of Epidemiology, Dept. Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA
Hemodialysis.com: What are the main findings of the study?
To our knowledge there has been no prior hemoglobin A1c (HbA1c) and blood glucose (BG) equation formula specific for hemodialysis patients, in spite of the increasing number of diabetic patients on dialysis, currently almost half of them. In this study, we sought to develop HbA1c-blood glucose equation models for hemodialysis patients and found equations as follows;
