Category Archives: Pediatric Nephrology
Pediatric RIFLE for Acute Kidney Injury Diagnosis and Prognosis for Children Undergoing Cardiac Surgery: A Single-Center Prospective Observational Study.
Hemodialysis.com eInterview with:
Written Interview conducted with author by Editor Marie Benz, MD
Hemodialysis.com: What are the main findings of the study?
Dr. Ricci: The main finding was that pRIFLE works properly in a relatively large cohort of neonates and infants with congenital heart disease. In fact it correlated strongly with predictive variables of AKI (cross-clamp time, inotropes and vasopressors use and surgical risk score) and it was also associated with prognostic factors (length of mechanical ventilation, length of intensive care unit stay and need for renal replacement).
Marie Benz, MD on Google+Long-term neurocognitive outcomes of patients with end-stage renal disease during infancy
Hemodialysis.com eInterview: Rebecca J. Johnson, PhD
Licensed Psychologist
Lead Pediatric Health Psychologist
Division of Developmental and Behavioral Sciences
Children’s Mercy Hospitals and Clinics
Assistant Professor, Department of Pediatrics
University of Missouri – Kansas City School of Medicine
Written Interview conducted with author by Editor Marie Benz, MD
Hemodialysis.com: What are the main findings of the study?
Dr. Johnson: We examined the long-term neurocognitive outcomes for 12 children (now an average age of 11 years) who were diagnosed with ESRD during the first 16 months of life. Across multiple indices of neurocognitive functioning, scores were lower than would be expected given a normal distribution, indicating that these patients are at risk for neurocognitive deficits. However, in the absence of major neurological risk factors, we did not find evidence of gross neurocognitive impairment. This finding is consistent with recent research, demonstrating that developmental outcomes have greatly improved for infants with ESRD over the last two decades.
Semaphorin 3A Is a New Early Diagnostic Biomarker of Experimental and Pediatric Acute Kidney Injury
Hemodialysis.com Interview with Dr. Ganesan Ramesh, Ph.D.
Associate Professor
Department of Medicine/Vascular Biology Center, CB-3702
Georgia Regents University
Augusta, GA 30912
Dr. Ramesh, would you please explain the background and potential usefulness of Semaphorin 3A in Acute Kidney Injury?
Acute kidney injury is a serious and frequent complication in hospitalized and ICU patients.
Currently used diagnostic test, serum creatinine is neither sensitive nor specific to detecting AKI early. This poses a problem for clinicians to intervene early to prevent the kidney damage further. Our aim is to identify a sensitive biomarker that can be used to diagnose kidney injury early and accurately, in a non-invasive manner.
In search for one such biomarker, we identified a protein called semaphorin 3A. Semaphorin 3A.
Impact of In-Home Education Programs on the Graduation Rate of Young Adults with Kidney Disease
Hemodialysis.com Author Interview: Lori L. Sanderson, PhD, LCSW
Lee Anne Gridley, Teacher
Peter Yorgin, Nephrologist
Hemodialysis.com: What are the main findings of the study?
Dr. Sanderson: In this study population, pediatric dialysis and transplant patients who did not attend home school were more likely to graduate from high school (OR: 3.778). Subjects who received home school were more likely to come from families of parents who did not attend college, completed high school, worked outside of the home, and spoke English as a second language. This study population was also more likely to be of Hispanic origin. They were also more likely to have received a kidney transplant rather than be receiving dialysis treatments.
Changes in Bone Matrix Mineralization After Growth Hormone Treatment in Children and Adolescents With Chronic Kidney Failure Treated by Dialysis
Hemodialysis.com Author Interview: Dr. Nadja Fratzl-Zelman
Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and
AUVA Trauma Centre Meidling,
1st Medical Department Hanusch Hospital, 1120 Vienna, Austria
Hemodialysis.com: What are the main findings of the study?
Dr. Nadja Fratzl-Zelman: Children and adolescents with chronic kidney disease (CKD) and growth deficiency are at risk of having low bone turnover and abnormally high bone matrix mineralization.
rhGh treatment improves patient height and concomitantly bone modeling/remodeling which appears beneficial for bone matrix mineralization
The quality of cardiovascular disease care for adolescents with kidney disease
Hemodialysis.com Author Interview: Uptal D. Patel, MD
Associate Professor of Medicine and Pediatrics
Divisions of Nephrology and Pediatric Nephrology
Duke University School of Medicine
Duke Clinical Research Institute Durham, NC 27705
Hemodialysis.com : What are the main findings of the study?
Cardiovascular disease is the leading cause of death for young adults who had kidney disease as children, and several recommendations for the assessment and treatment of cardiovascular risk factors in adolescents with kidney disease have been promulgated over the past decade.
