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February 27, 2013 Dialysis Modalities, Frequency, Interviews, JASN, Outcomes No comments

High-Efficiency Postdilution On-Line Hemodiafiltration Reduces All-Cause Mortality in Hemodialysis Patients

Hemodialysis.com Author Interview:

Dr. Francisco Maduell
Department of Nephrology and Renal Transplantation
Hospital Clinic, University of Barcelona
Villarroel, 170 – 08036 Barcelona, Spain.

Hemodialysis.com: What are the main findings of the study?

Dr. Maduell: The results of the ESHOL trial indicate that high efficiency postdilution OL-HDF reduces all-cause mortality versus conventional hemodialysis in prevalent patients.

Furthermore, the main causes of mortality, cardiovascular and infectious diseases, were significantly reduced by OL-HDF. The incidence rate of dialysis sessions complicated with hypotension episodes and all-cause hospitalization were lower in patients randomized to OL-HDF

Marie Benz, MD on Google+

Patient Resources

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  PO Box 2040, 3000 CA Rotterdam, the Netherlands.
  
  Hemodialysis.com: What are the main findings of the study?
  
  Dr. Stads: Acute Kidney Injury requiring renal replacement therapy is associated with high in-hospital mortality. Little is known about renal recovery in surviving patients and the impact of impaired kidney function on long-term renal and overall survival.
  
  In a retrospective cohort study, we evaluated the association between impaired kidney function at hospital discharge with long-term renal and overall survival. The median follow up in our cohort was 8.5 years (range 1-17 years). Only 35% (n=170) of patients in our cohort were discharged with an estimated GFR > 60 ml/min per 1.73m². An estimated GFR < 30 ml/min per 1.73m² was a strong and independent predictor for decreased long-term survival and poor renal survival.
  
  Marie Benz, MD on Google+
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