Tag Archives: peritoneal dialysis
Current Status and Practical Use of Effluent Biomarkers in Peritoneal Dialysis Patients
Hemodialysis.com eInterview with
Raymond T Krediet, MD,PhD
Professor of Nephrology
Division of Nephrology, Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
Hemodialysis.com: What are the main findings of the study?
Dr. Krediet: The review summarizes the current knowledge and potential use of substances, that are present in drained peritoneal dialysate due to local production or release, also called effluent biomarkers. Some of these may give a mirror image of certain morphological changes in the peritoneum. Examples are cancer antigen 125 (CA125), that reflects the mesothelial cell mass, interleukin-6, (Il-6) which indicates peritoneal micro-inflammation in the absence of peritonitis, and plasminogen activator inhibitor-1. An example is given of a patient, in whom an earlier diagnosis of encapsulating peritoneal sclerosis (EPS) would have been possible with the use of biomarkers during his follow-up.
Marie Benz, MD on Google+Heart Failure with Preserved or Reduced Ejection Fraction in Patients Treated With Peritoneal Dialysis
Hemodialysis.com Interview with
Angela Yee-Moon Wang, MD, PhD, FRCP
Research performed at Prince of Wales Hospital, Chinese University of Hong Kong
Current affiliation: Dept of Med, Queen Mary Hospital, University of Hong Kong
Hemodialysis.com: What are the main findings of the study?
Dr. Wang: This prospective study is so far the first to investigate the prevalence of heart failure with preserved ejection fraction (HFPEF) and compare the long-term clinical outcomes of heart failure with preserved or reduced ejection fraction in the dialysis population and specifically in the peritoneal dialysis (PD) patients.
We observed a very high prevalence of heart failure with preserved ejection fraction (HFPEF) (~ 55%) in the PD patients, suggesting that this is a very common heart failure entity in the PD patients. Furthermore, our study is the first to show that PD patients having HFPEF were associated with an increased risk of mortality and adverse cardiovascular outcomes including cardiovascular death, fatal or non-fatal cardiovascular events, and heart failure compared to patients without heart failure. However, the risk for all-cause mortality, cardiovascular death, fatal or non-fatal cardiovascular events, and heart failure was lower when compared to patients having heart failure with reduced ejection fraction (HFREF).
Cost Analysis of Hemodialysis and Peritoneal Dialysis Access Costs in Incident Dialysis Patients
Hemodialysis.com: Dr.Luis Coentrão
Nephrology Research and Development Unit
Faculty of Medicine, University of Porto & São João Hospital Centre
Alameda Professor Hernani Monteiro, Porto, 4202-451, Portugal
Hemodialysis.com: What are the main findings of the study?
Dr. Coentrão: Both peritoneal catheters and arteriovenous fistulae are safe and effective dialysis accesses for incident dialysis patients.
Hemodialysis.com: Were any of the findings unexpected?
Dr. Coentrão: Peritoneal dialysis patients had fewer dialysis access-related invasive procedures in comparison with hemodialysis patients with central venous catheters and fistulae.
Prognostic factors of all-cause mortalities in CAPD
Hemodialysis.com Author Interview:
Phisit Vejakama, MD
Section for Clinical Epidemiology and Biostatistics, Faculty of Medicine,
Ramathibodi Hospital, Bangkok, Thailand
Bundarik Hospital, Thailand
Hemodialysis.com: What are the main findings of the study?
Dr. Vejakama: The cutoffs of 0.25 and 1.75 for rKt/V and tKt/V were associated with mortality in CAPD patients. The tKt/V higher than 2.19 did not result in any further benefit. The rKt/V was a much more potent predictor of mortality than the tKt/V (suggesting that renal clearance is more important than peritoneal clearance) and the tCrcl did not have any additional value over Kt/V. Higher serum albumin, hemoglobin, systolic blood pressure, and ultra-filtration volume were associated with lower mortality.
